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Since the NS3 helicase translocates in a 35-helicase direction, the 3 end of the X tail is the potential binding and initiation site

Crosstalk through PERK Protein kinase-RNA like ER kinase branch can induce NF-B activation essentially by translation attenuation, including the free IB, mediated by phosphorylated eIF2

It plays a key part in boosting neuronal health and the micronutrients deficiency has been associated with oxidative stress, programmed cell death and necrosis of neurons eventualizing into a plethora of neurodegenerative disorders (Vali et al., 2025)

We also review the recent progress in attenuating the molecular mechanisms of the NF-kB Pathway by phytochemicals, which may open up novel therapeutic avenues

Aside from the rapid development of the acquired resistance, the limited targeting of specific KRAS mutations poses another significant challenge for drug development, given the diversity of oncogenic KRAS mutations